LA JOLLA, Calif.–(BUSINESS WIRE)–DermTech, Inc. (NASDAQ: DMTK) (“DermTech” or the “Company”), a leader in precision dermatology enabled by a noninvasive skin genomics platform, today announced the publication from “Noninvasive Genomic Characterization of Patients with Chronic Nonsclerotic and Superficially Sclerotic Cutaneous Graft-vs-Host Disease Identified a Novel Genetic Signature in Responders to Ruxolitinib Cream,” in Transplantation and Cellular Therapy.
Graft versus host disease (GvHD) occurs when the immune cells of the transplanted donor attack healthy cells and tissues of the recipient. Dermatological manifestations are an important aspect of GvHD, as they are often the first organ affected in GvHD and develop in more than half of patients with GvHD. While oral ruxolitinib, a JAK1/2 inhibitor, has been approved by the US Food & Drug Administration (FDA) for the treatment of acute and chronic GvHD (cGvHD), this is the first clinical trial evaluating the efficacy of topical ruxolitinib in cutaneous GvHD patients.
Skin samples were collected non-invasively from patients with cutaneous GvHD using the DermTech Smart StickerMT and then analyzed by RNA sequencing to study the effect of topical ruxolitinib on gene expression in cGvHD. Specifically, the study assessed genomic differences between treatment with ruxolitinib cream and vehicle cream and the distinction between patients who responded to treatment and those who did not.
“Noninvasive characterization and prognosis of therapeutic response is necessary for GvHD therapies,” said Dr. Alina Markova, lead author and assistant dermatologist at Memorial Sloan Kettering Cancer Center. “This is the first study to characterize the effect of topical JAK1/2 blockade with ruxolitinib cream on cutaneous GVHD and to differentiate genomic signatures between responders and non-responders.”
Bioinformatics analyzes of Smart StickerMT collected skin samples successfully identified 210 differentially expressed genes (DEGs) between topical ruxolitinib and in-vehicle treatments with primary pathway differences in immune modulation and cell signaling. Additionally, 383 DEGs have been identified that differentiate patients who responded to treatment from those who did not.
“We are proud to partner with Memorial Sloan Kettering Cancer Center to advance research into the treatment of patients with cutaneous GvHD and provide clinicians with objective genomic information to help identify patients who may benefit from treatment,” said Michael Howell, PhD, Chief Scientific Officer of DermTech. “This collaboration once again demonstrates DermTech Stratum’s capabilities to offer translational medicine services to bring greater precision and personalization to the diagnosis and treatment of dermatological diseases.
For more information about DermTech Stratum, visit https://dermtechstratum.com/.
DermTech is a leading genomics company in dermatology and is creating a new category of medicine, precision dermatology, made possible by its non-invasive skin genomics platform. DermTech’s mission is to improve the lives of millions of people by providing non-invasive, precision dermatology solutions that enable individualized care. DermTech provides genomic analysis of non-invasively collected skin samples using our smart stickersMT. DermTech markets and develops products that facilitate the early detection of skin cancers and develops products that assess inflammatory diseases and personalize drug treatments. For more information, please visit DermTech.com.
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